Advantage Dog – Topical Flea Treatment. Use Advantage monthly to kill fleas within minutes. The active ingredient is imidacloprid, which acts on the nervous system of the flea to cause paralysis and subsequent death. Advantage stops biting fleas in three to five minutes and starts to kill adult fleas within an hour after application. Within 12 hours of application, 98-100 percent of fleas are dead. This is important because flea bites can lead to skin infections, cause discomfort for your pet, lead to allergic skin reactions, and can even transmit other disease-causing organisms, including tapeworms. You won’t need to use another flea control product. Advantage kills fleas before they lay eggs, so their life cycle is broken at multiple stages. Advantage for dogs should not be used on any other type of animal. Always consult your veterinarian prior to application. Each box contains a 4 month supply (4 doses). Benefits: – Stops biting fleas in three to five minutes – Kills 98 – 100 percent of fleas within 12 hours – Kills reinfesting fleas within two hours – Kills flea larvae within 20 minutes – Remains effective after swimming or shampooing – Protects from fleas all month long Sizing: Green Box (GRN): For Dogs 0-10 lbs Teal Box (TL): For Dogs 11-20 lbs Red Box (RD): For Dogs 21-55 lbs Blue Box (BL): For Dogs 55 lbs and up